We have extensive expertise in production, isolation, purification, lyophilization, cell culture and testing of proteins, adhesion peptides, attachment factors, substrate rigidity, and other 3D matrix products. Our expertise and knowledge is being employed to assure that our products are of the highest quality, are consistent from lot-to-lot and are easy-to-use for our research customers.
Transforming science to a new level of discovery by providing advanced technologies through innovative 3D matrix products.
Advanced BioMatrix is located in the San Diego, California region which has the largest biotech cluster. Its state-of-the-art facility located in Carlsbad, California includes manufacturing clean rooms, quality control laboratories, and R&D suites to ensure and support product quality and development of new innovative products.
Why 3D Matters:
3D gels allow for the study of the effects of the mechanical properties of the ECM, such as density and rigidity, on cell development, migration, and morphology. Unlike 2D systems, 3D environments allow cell extensions to simultaneously interact with integrins on all cell surfaces, resulting in the activation of specific signaling pathways. Gel stiffness or rigidity also affects cell migration differently in 3D versus 2D environments. Furthermore, integrin-independent mechanical interactions resulting from the entanglement of matrix fibrils with cell extensions are possible in 3D systems, but not in 2D systems where the cells are attached to a flat surface.
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