Aprecia Pharmaceuticals

Aprecia is a specialty pharmaceutical company that's committed to enhancing customers' experience with highly prescribed high-dose medications. Built upon our innovative and proprietary three-dimensional printing (3DP) technology platform, we focus on opportunities where there is a need for medicines that are easy to take.

Profile Description

We believe Aprecia is the first and only company in the world utilizing this cutting-edge 3DP technology platform to develop and manufacture pharmaceutical products on a commercial scale. We believe our platform will generate multiple product-enhancing drug delivery technologies that can be used in a variety of therapeutic categories. Our first innovation that leverages 3DP is ZipDose® Technology, which will be utilized in multiple product candidates.1
ZipDose® Technology is based on a simple premise: medicine should be simple for caregivers to administer and for patients to swallow.

Harnessing the power of 3DP to develop innovative medicines

Powder-liquid three-dimensional printing (3DP) technology was developed at the Massachusetts Institute of Technology (MIT) in the late 1980s as a rapid-prototyping technique. This technology uses an aqueous fluid to bind together multiple layers of powder using a unique, patent-protected process to create a wide range of products.

This work was expanded into the areas of tissue engineering and pharmaceutical use from 1993 to 2003. Over the years, this process and related layered-manufacturing techniques have been used to fuel innovation and progress across various industries. From fabricating automotive parts to crafting intricate biological structures, this process has proven invaluable, with significant untapped potential.

Pharmaceutical rights to MIT’s 3DP process are exclusively licensed to Aprecia. Seeing an opportunity to improve the patient experience of taking medications, Aprecia is applying advanced 3DP techniques to the realm of pharmaceutical products.

Bringing ZipDose® Technology to life

Using our proprietary 3DP manufacturing process, Aprecia developed the ZipDose® platform, which is designed to enable delivery of high-dose medications in a rapidly disintegrating form. ZipDose® Technology produces a product layer-by-layer without using compression forces, punches, or dies. First, a powder blend is deposited as a single layer. Then, an aqueous binding fluid is applied and interactions between the powder and liquid bind these materials together.

This process is repeated several times to produce solid, yet highly porous formulations, even at high dose loading. Aprecia’s ZipDose® products are designed to:

  • Rapidly disintegrate on contact with liquid by breaking the bonds created during the 3DP process
  • Support dose loading up to 1,000 mg
  • Allow the application of enhanced taste-masking techniques

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